File:ΔFosB.svg
Original file (SVG file, nominally 935 × 965 pixels, file size: 238 KB)
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Summary
DescriptionΔFosB.svg |
English: The finished, wikilink annotated version is currently located at en:Template:Psychostimulant addiction; a more detailed image caption is located there as well. For external (off-wiki) use, a screenshot of the annotated version is located at File:Annotated ΔFosB.svg screenshot.png. This image shows the signal transduction that occurs in nucleus accumbens D1-type medium spiny neurons that gives rise to psychostimulant addiction. This signaling cascade occurs during chronic high-dose use of certain dopaminergic stimulants (e.g., phenethylamine, methamphetamine, amphetamine, etc.). Cocaine induces a slightly different signaling cascade than the one shown here.
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Date | |
Source | Own work |
Author | Joseph Mickel (Seppi333) |
Other versions | File:Annotated ΔFosB.svg screenshot.png - labeled version |
Associated ΔFosB expression graph InfoField | File:ΔFosB accumulation.svg – shows how ΔFosB is induced following acute and repeated drug exposure and how it accumulates in neurons with repeated exposure to addictive drugs. |
Presynaptic diagram InfoField | File:TAAR1 Dopamine.svg – illustrates the other side of the synaptic cleft for amphetamine and endogenous phenethylamine. |
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Annotations InfoField | This image is annotated: View the annotations at Commons |
Top: ΔFosB
Bottom: JunD
This complex is the activator protein 1 transcription factor.
Items portrayed in this file
depicts
15 June 2014
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 19:41, 9 November 2016 | 935 × 965 (238 KB) | wikimediacommons>Seppi333 | added 1 gene product box for AC in the cAMP pathway |
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Width | 935 |
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Height | 965 |